I'm looking to fit the same combo on my 77. I fabbed up a tool to check clearances and it looks like the 295-50 on a 10x15 with a 4.5 backspace will fit, but JUST barely. plenty of clearance on the inside, very close on the outside. My truck is lowered 4.5 and 6 as well. One of my neighbors is running this combo on a 72 with widened bed tubs. I'm going to measure the actual width of the mounted tire to get a definitive answer. I'll post the result soon.