That's kind of a loaded question since there are several undefined variables. The following scenario should help convey the idea. Certainly, other scenarios exist. Assuming four, DOT approved headlamps at ~60 watts each for estimating purposes, the maximum headlamp draw will be ~240 watts, equating to ~20 amps; add another 10 - 14 amps for running lamps; windshield wiper motor on high speed ~20 amps, and power windows rolling up/down ~25 amps. So driving at night in heavy rain with the headlamps on high beam while rolling a window up conceivably could draw as much as ~80 amperes, if only for a few moments.
You definitely don't want to lose the function of safety items like headlamps, w/w or power windows, especially at the same time at night, so you need to plan conservatively. Allowing for a 20-amp margin, the B+ cable feeding the junction block should be able to safely carry 100 amps at a maximum voltage loss of ~5%. The supply cable's insulation should be able to tolerate high temperature, abrasion and typical automotive chemicals, so specify SXL wire. Assuming a B+ cable length of ~10 feet, 8-gauge stranded copper wire is the absolute miniumum wire size to consider, with 6-gauge being a better choice. To protect the junction block B+ cable, install a 100-amp ANL, MIDI or MRBF fuse near the battery, or substitute a 6" long, 12-gauge fusible link for the 8-gauge cable or a 10-gauge fusible link for the 6-gauge cable. In addition, each appliance (headlamps, w/w, power windows) needs to be independently protected by an appropriatly rated fuse or circuit breaker. Bear in mind that the headlamp switch has two B+ feeds that are independently protected, one for the headlamp circuit and one for the running lamp circuit. The instrument lamps are redundantly protected by the 20-amp running lamp fuse and the 5-amp instrument lamps fuse. Select a junction block with at least a 5/16" diameter stud.