Changing the pinion seal is relatively easy and doesn't offer up one of those, while you're in there you might as well opportunities when it comes to changing the final drive ratio. Unfortunately that is a bit more involved and better suited for the experts if you do not have the tools and knowledge.
If you are considering changing ratio's and want opinions you should list more details about your truck, what engine, trans, tire size etc.
Changing the pinion seal basically chock the wheels, witness mark and remove the driveshaft from the companion flange, witness mark and index the nut, shaft and flange, remove the nut, remove the yoke (companion flange) and remove the seal. Make sure it is clean and apply a small amount of liquid Teflon to the splines. Reinstall in reverse of removal and top off the fluid.