I run a similar setup:
FRONT: 15x8, 4" backspacing, 245/60-15 Radial T/A
REAR: 16x10, 5" backspacing, 295/50-16 Radial T/A
What I consider to be perfect fitment for my application. My truck is lowered 2' in front and 4" in the rear. No clearance issues.