If it's a stock or near stock engine, it may actually run better, if scavenging improves. Just make sure the y-pipe transition is nice and smooth. Keep in mind that even mildly modified F-bodies run great on single 3" systems.
But then again if you already have a dual 2.5" installed, I would be inclined to keep it and put in an H-pipe or X-pipe crossover to improve scavenging.