First of welcome to the site. I am assuming it is a C-10 Pickup ? A little more info would help us out here.
I am assuming it is a 700 R4 Automatic transmission since you said 1-2-3-and 4th gears ? Even though a 76 did not come with a overdrive transmission. Or could it be you have the turbo 350 and just think you have 4 gears ?
Since you said it only happens in the higher gears, so that means that you are going faster. Does it only happen at higher speeds and not lower speeds ?
Some things to consider. If it only happens at higher speeds, and unless your 3rd ( or 3rd & 4th gear in a 700 R4 trans) gear is just blown on your transmission (which would make it drive not so nicely in that gear), or the oil valleys going to those gears are somewhat plugged/plugged in your trans (I do not know where the metal sound would come from at all), I would look outside the transmission for the metal to metal sound.
Remember at higher speeds you are applying more torque from the engine/trans combo. Have you looked from the engine bay (bottom of engine) all the way back to the rear axle for any signs of wear marks that should not be there ? Pay special attention to the drive shaft area.
You mentioned loss of pressure on your brakes, dumb question but have to ask, did you look at all your disk/drums yet to see how they look and the pads look ?
There will be more comments I am sure, but start there for now.