I'm thinking if you aren't going to tow regularly with 454 cubes, and a 4sp, you can get away with a little bigger than most. The 781s flow like the Mississippi River, so good start there. I recommend a hydraulic roller, something in the 280 advertised duration range. And a Performer RPM intake. Top it off with a 750 Holley vacuum secondary carb, and you'll run out of money buying u-joints, and tires.
I have a 454 with 049s (same as 781s just different year). I have a solid cam, and a Holley Strip Dominator intake. 750 Holley carb. Even with my "high RPM" build the 454 (actual 461) gives me enough torque to baste the back tires at will. I also cut in 2.19in/1.88ex valves and pocket ported the heads. I spin my engine 7,000rpm a lot.