I currently have a ZF6 from a 2002 Chev sitting, waiting for a transplant into my 1986 1 ton.
The 6 speed is a 2wd version, I got lucky......34000 km on the trucks odometer and I paid $1000 for the transmission. I also already had a divorced NP205 sitting around anyways.
The ZF6 is a big transmission, it's tall, long and heavy (about 220 lbs or so) and slightly worries me that I will need a body lift to even fit it under my floor. Either that or some good transmission hump modifications.
I wouldn't be looking for one specifically, in fact I would more so lean towards the NV4500 due to its size and availability. That being said, I found mine by accident and it was the same price as what people wanted for a used 4500 with more miles on it, so I wasn't about to turn it down.
I'm actually sorry now I didn't take the 8.1L that was bolted to it for the extra $1000

My bottom line I guess, if you find one cheap and in good shape, go for it. But if you have something like a 2wd half ton, there are other 6 speed options out there that would do fine.