It is pretty simple, but a large undertaking. Kind of a double negative there! It can be done with a decent set of hand tools, plenty of weasel pee, some brute force and ignorance. Oh yeah, and several friends if you don't have a way to lift the cab. Four bolts for the mounts, two more for the core support, steering column, brake lines, wiring, shift linkage and or clutch line / linkage are the basics.
If your two wheel drive in an auto trans you will need to cut out the center floor hump and use the one from the 4x4.
If one is standard and the other auto you will need to do some switching around there possibly.
If one or the other has dual tanks you will have to deal with that.