"This is just such an odd design, to me, having such inaccessible parts, or in this case most of the engine, and the spark plugs especially."
I don't understand. Are you working on a squarebody, or have I misunderstood? I have found the squarebody engine bays to be quite accessible, plugs and all. If you are working on the step van in your picture, then I understand. On a squarebody, I agree that reaching everything is a bit of a chore because of height (if climbing in the engine bay is not an option), but that would be true of any pickup. The engine creeper looks intriguing, but with a dirt floor, I see why that's not really an option, either.
By the way, if we are talking about a squarebody it is possible to remove the front fenders without removing the hood, but it does eliminate the hood springs. You have to prop the hood with something else, which is somewhat hazardous. At any rate, removing the fenders will be frustrating, too. They attach at the A-pillar (top and bottom), several bolts attaching the inner fender to the outer fender, one large inner fender bolt to the lower firewall, a few bolts to the radiator support, and two bolts for the front filler panel between the grille and the bumper, which will necessitate removing the grille and headlight trim. Any of these bolts may be rusted. Before I would disassemble the entire front clip, I would probably just cobble together a stable stool made out of 2x4s and plywood with steps at a couple of different heights. Good luck to you my friend, and may you get it back on the road soon!