if it is a new engine, they are usually pointing to #1 cylinder on fire stroke. So, might as well continue that practice....check to see if #1 piston is up and put the distributor in anyway, just ensure the rotor points in the direction of where the #1 will be when cap is placed on. Then just put the wires on. If you have vacuum advance, ensure if you have some play room to adjust timing where the diaphram wont hit up against the firewall and your vacuum line to advance is long enough. Aside from that, it doesnt matter how the distributor is placed in.
Each has their own way to break in a cam, but, most of what I read and done is to maintain the rpms initially at around 2,000 for about 15 to 20 minutes. Don't forget that.