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Wouldn't a higher compression ratio and high lift cam by themselves lower mpg's? If you did those two things to allow you to run an ultra high gear maybe?
UPdate: New strategies for increased mpg, in my opinion:Think ----higher compression and/or cam---mega rv type cam with massive bottom end torque and no top end.-----jet down smaller in the carb.-----electronic fuel injection is getting a little cheaper.-----keep it at or below 65mph.