How many RPMs do you plan on turning? Stock stall speed converter? If not over 6,000 on the max RPMs I would stay with the oval port heads, Holley Strip Dominator intake, and a strong low end hydraulic roller cam. Add a 4160 Holley 750 vac secondary carb to it for good off the line response.
If you aren't going to a larger stall converter then you will need to build for low end grunt.