Welcome to the site. That's kind of a loaded question that begs a lot of assumptions. What is your intention for the "new" motor? What did you have done 1,500 miles ago? What happened to the motor in the meantime that you want to replace major components? If all you are trying to do is freshen the motor, why new pistons? It's difficult to provide a useful answer without sight of the entire picture.
Pistons need to fit their bores with the proper clearance. At the very least, you should carefully measure the bore diameter, runout, taper and deck height then compare the measurements to the new pistons and rotating assembly you are planning, and machine accordingly. While its apart, check for cracks and have the line bore checked. You might even consider clearancing the block for a 3.75" stroke in case you later get the bug.