If it is true full time 4x4, then you could do it, but you would have to put the transfer case into hi-lock, which would defeat the purpose. I had a 76 K-10 full time, I just made sure that everything was greased and in good shape and drove it every day for over a year(in regular Hi, not hi-lock) and it did fine. These were weant to be driven everywhere, just like anything else. So, yes, you would be fine as long as all u-joints and fluids are good.