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To me I like a surround sound, get some high's in the dash or overhead. Kick panel speakers or door speakers, boxes behind the seat or where you are putting the 6X9"s and a sub
To be honest, 2 full size 10"s will sound a whole lot better than 1 low profile 12".And as far as wiring them all on the same amp, don't. For the most part and decent head unit will drive 6x9s and if not, get component 6x9s that come with their own little amps.Subs generally get their own amp.