Ricky,
as for the swap, It will be just a standard engine replacement. Get a good manual for your truck, Label all your electrical and vacuum lines, take a lot of pictures and you'll be fine.
As for the tune, I don't think you'd have any tuning issues with a 350 with a rv style camshaft, it's not that radical of a change from the stock camshaft, just a little longer duration.
Stark