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It's gonna get worse..........LOL you knew that already, My guess is about 2mpg. But look at the good side the truck will feel like you have 35-50 more hp.
You will need a hybrid u-joint though...
If your 10 bolt is the standard 1310 u joint series and the 12 bolt is the standard larger 1330 series this is what you can use. http://www.summitracing.com/parts/PCN-253/
He should know what you want unless they are under the age of 25.,..
Don't you need to change the rear wheels as well? I thought that only the 4wd models had the 12 bolt.
every thing prior to 1981 used 12 bolts, everything after used 10 bolts (an yes there are exceptions as they were using up the remaining 12's)