When i built mine it was meant to be a street/strip toy so mileage was never a factor. With that said I run a 30" tall tire, 4.11 gears and a 1:1 high gear as would also be found in all TH350's and 400's. At 55mph I turn a solid 2900 RPM. I dont have any idea what it gets for mileage, heck i'd hate to even know. The taller 35" tires would help but not a lot. Overdrive would definitely help but then so would higher gears. I dont think 10-12 mpg is out of the question for any of those combos if geared right. 454s make a mountain of low end torque but if you pair them with low gears you can expect more like 7-8mpg