sure....only use RTV when necessary and use this kind

Always install all bolts before tightening any and torque to specs with a torque wrench.
For the intake manifold, ditch the end seals and use a center punch to make a series of impressions along the ridge. Use RTV instead of the end seals.
If you have a 2 piece rear main seal, offset the seal so that the ends don't line up with the bearing cap.